Nanotechnology at the crossroads of stem cell medicine.

IF 5.8 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2024-11-25 DOI:10.1039/d4bm01257g

Sweny Jain, Jay Bhatt, Sharad Gupta, Dhiraj Devidas Bhatia

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Abstract

Nanotechnology in stem cell medicine is an interdisciplinary field which has gained a lot of interest recently. This domain addresses key challenges associated with stem cell medicine such as cell isolation, targeted delivery, and tracking. Nanotechnology-based approaches, including magnetic cell sorting, fluorescent tagging, and drug or biomolecule conjugation for delivery, have enhanced precision in stem cell isolation and guided cell migration, increasing the therapeutic potential. Recent studies have focused on using nanomaterials and scaffolds to drive stem cell differentiation by activating specific molecular pathways, achieved through embedding biomolecules within the scaffold or through the scaffold's material composition and structure alone. These innovations hold promise in therapeutic applications across various diseases, including cancer stem cell targeting, neurodegenerative disorders, pre-eclampsia, cardiovascular conditions, and organoid development. This review examines recent advancements in the field, explores potential applications like biosensors and nanochips, and highlights the challenges and research gaps.

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处于干细胞医学十字路口的纳米技术。

干细胞医学中的纳米技术是一个跨学科领域，近来备受关注。这一领域解决了与干细胞医学相关的关键难题，如细胞分离、定向输送和跟踪。以纳米技术为基础的方法，包括磁性细胞分拣、荧光标记和药物或生物大分子连接输送，提高了干细胞分离和引导细胞迁移的精确度，增加了治疗潜力。最近的研究侧重于使用纳米材料和支架，通过在支架内嵌入生物分子或仅通过支架的材料成分和结构，激活特定分子途径，从而驱动干细胞分化。这些创新有望应用于各种疾病的治疗，包括癌症干细胞靶向、神经退行性疾病、子痫前期、心血管疾病和类器官发育。本综述审视了这一领域的最新进展，探讨了生物传感器和纳米芯片等潜在应用，并强调了面临的挑战和研究空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.