Bio-catalytic activity of novel poly(ethylene glycol) methacrylate hybridized silver nanomaterials

IF 2.7 3区生物学 Q2 PLANT SCIENCES

South African Journal of Botany Pub Date : 2024-11-26 DOI:10.1016/j.sajb.2024.11.017

Natasha Anwar , Mohib Shah , Saad Haroon Anwar , Muhammad Ishaq Ali Shah , Amirzada , Hammad Ahmad Jan , Abeer Hashem , Graciela Dolores Avila-Quezada , Elsayed Fathi Abd-Allah

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Abstract

The widespread extensive use of common antibiotics and increase in drug-resistant bacterial strains have attained focus on the search for novel and effective antiproliferative agents. This study uses Periploca aphylla Dcne's as reducing and stabilizing agents to produce stable poly (ethylene glycol) methacrylate hybridized silver nanomaterials (PEGMA-AgNPs) with controlled physicochemical and biological properties in an environment friendly manner.

The study revealed that poly (ethylene glycol) methacrylate (PEGMA) coating had no effect on the crystal structure of Periploca aphylla Dcne's capped silver nanoparticles (Pe-AgNPs) which shows that only physical interactions took place during capping.

Characterization techniques like UV–visible spectrophotometer (UV), Fourier transform infrared spectroscopy(FTIR), scanning electron microscope (SEM), energy dispersive X-ray (EDX), transmission electron microscope (TEM), Zeta potential (ZP), and dynamic light scattering (DLS) were used. Relationships between the physicochemical properties of Pe-AgNPs, including synthesis, temperature, pH, and salt were studied. The produced PEGMA-AgNPs, which had a spherical shape and a negatively-charged Zeta potential of -20.2 mV, were stable in colloidal form for six months, as evidenced by a single symmetric surface plasmon resonance (SPR) band at 425 nm.

Pe-AgNPs and PEGMA-AgNPs used against PC-3 human prostate adenocarcinoma cell line and in addition, they also exhibited up-regulated anti-proliferative activity to this cell line. These results showed that gels and films which can be loaded with PEGMA-AgNPs may have potential as antiproliferative systems. Catalytic activity of the Pe-AgNPs and hybrid system were tested by choosing the catalytic reduction of 4-nitrophenol (4-NP) as a model reaction. Both synthesized Pe-AgNPs and PEGMA-AgNPs exhibits catalytic activity for the reduction of 4-NP to 4-aminophenol. Surprisingly however among various kinds of Pe-Ag nano-composites investigated only those stabilized by PEGMA had high catalytic activity. The study revealed that PEGMA-AgNPs exhibited strong antioxidant, cytotoxic, anti-diabetic and antileishmanial properties.

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新型聚（乙二醇）甲基丙烯酸酯杂化银纳米材料的生物催化活性

随着普通抗生素的广泛使用和耐药菌株的增加，人们开始关注新型有效的抗增殖剂。本研究利用茜草萃取物作为还原剂和稳定剂，以环境友好的方式制备稳定的聚（乙二醇）甲基丙烯酸酯杂化银纳米材料（PEGMA-AgNPs），并控制其物理化学和生物学特性。研究发现，聚（乙二醇）甲基丙烯酸酯（PEGMA）涂层不会影响 Periploca aphylla Dcne 冠层银纳米粒子（Pe-AgNPs）的晶体结构，这表明在冠层过程中只发生了物理相互作用。表征技术包括紫外可见分光光度计（UV）、傅立叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、能量色散 X 射线（EDX）、透射电子显微镜（TEM）、Zeta 电位（ZP）和动态光散射（DLS）。研究了 Pe-AgNPs 的理化性质之间的关系，包括合成、温度、pH 值和盐。所制备的 PEGMA-AgNPs 呈球形，带负电荷的 Zeta 电位为 -20.2 mV，胶体状态在 6 个月内都很稳定，425 nm 处的单一对称表面等离子体共振（SPR）带证明了这一点。Pe-AgNPs 和 PEGMA-AgNPs 用于对抗 PC-3 人类前列腺癌细胞系，此外，它们还对该细胞系表现出上调的抗增殖活性。这些结果表明，可负载 PEGMA-AgNPs 的凝胶和薄膜可能具有作为抗增殖系统的潜力。通过选择 4-硝基苯酚（4-NP）的催化还原作为模型反应，测试了 Pe-AgNPs 和混合体系的催化活性。合成的 Pe-AgNPs 和 PEGMA-AgNPs 都具有将 4-NP 还原成 4- 氨基苯酚的催化活性。但令人惊讶的是，在所研究的各种 Pe-Ag 纳米复合材料中，只有那些由 PEGMA 稳定的复合材料具有较高的催化活性。研究表明，PEGMA-AgNPs 具有很强的抗氧化、细胞毒性、抗糖尿病和抗利什曼病特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

South African Journal of Botany 生物-植物科学

CiteScore

5.20

自引率

9.70%

发文量

709

审稿时长

61 days

期刊介绍： The South African Journal of Botany publishes original papers that deal with the classification, biodiversity, morphology, physiology, molecular biology, ecology, biotechnology, ethnobotany and other botanically related aspects of species that are of importance to southern Africa. Manuscripts dealing with significant new findings on other species of the world and general botanical principles will also be considered and are encouraged.