Carboxymethyl chitosan and sodium alginate oxide pH-sensitive dual-release hydrogel for diabetes wound healing: The combination of astilbin liposomes and diclofenac sodium

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2024-11-12 DOI:10.1016/j.carbpol.2024.122960

Xiaoyu Wu , Yulai Wang , Xinglong Liu , Qiteng Ding , Shuai Zhang , Yue Wang , Guodong Chai , Yan Tang , Junran Yang , Taojing Yu , Wencong Liu , Chuanbo Ding

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引用次数: 0

Abstract

Difficulty in diabetic wound healing presents a significant challenge in clinical practice. This study developed a hydrogel utilizing oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS) as the matrix. Astilbin (ASB), known for its antioxidant properties, was incorporated into Astilbin liposome (AL) using a thin film dispersion method. Diclofenac sodium (DS) and AL, both possessing anti-inflammatory properties, were then encapsulated in the hydrogel to create a pH-responsive dual-release system for topical application to expedite diabetic wound healing. Results from the research demonstrate that the composite hydrogel exhibits favorable biodegradability, stable rheology, and swelling capacity, facilitating the controlled release of AL and DS. In vivo and in vitro data demonstrated that the hydrogel was biocompatible and anti-inflammatory, antibacterial and homeostatic, and significantly promoted the process of inflammation suppression, angiogenesis and fibrotic repair of wounds. In conclusion, this novel hydrogel provides a simple and effective method for the repair of chronic diabetic wounds.

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用于糖尿病伤口愈合的羧甲基壳聚糖和氧化海藻酸钠 pH 值敏感型双释放水凝胶：芪醇脂质体与双氯芬酸钠的结合

糖尿病伤口愈合困难是临床实践中的一大挑战。本研究利用氧化海藻酸钠（OSA）和羧甲基壳聚糖（CMCS）作为基质，开发了一种水凝胶。采用薄膜分散法将以抗氧化性著称的阿斯利滨（ASB）加入阿斯利滨脂质体（AL）中。然后将具有抗炎特性的双氯芬酸钠（DS）和 AL 包裹在水凝胶中，形成了一种 pH 值响应型双释放系统，用于局部应用以加快糖尿病伤口的愈合。研究结果表明，复合水凝胶具有良好的生物降解性、稳定的流变性和膨胀能力，有利于 AL 和 DS 的控制释放。体内和体外数据表明，该水凝胶具有生物相容性、抗炎、抗菌和同化作用，能显著促进伤口的炎症抑制、血管生成和纤维化修复过程。总之，这种新型水凝胶为慢性糖尿病伤口的修复提供了一种简单有效的方法。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.