Mass drug administration to eliminate lymphatic filariasis: A population-based coverage and compliance study in Eastern India

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-11-01 DOI:10.1016/j.cegh.2024.101860

Shubhashisha Mohanty , Birasen Behera , Abhinav Sinha , Madhusmita Bal , Sanghamitra Pati , Prakash Kumar Sahoo

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引用次数: 0

Abstract

Background

Neglected tropical diseases (NTDs) like lymphatic filariasis (LF) affect over 1 billion people globally, with India being a significant hotspot. Challenges persist despite global and national efforts, including the World Health Organization's (WHO) Global Program to Eliminate Lymphatic Filariasis (GPELF) and India's National Filaria Control Programme. We conducted a study to assess the coverage and compliance of mass drug administartion (MDA) to improve LF elimination efforts in the Khordha district of Odisha, India.

Methods

A sample of 2281 participants, including both males and females aged two years or older, was chosen through multistage stratified sampling. These participants were interviewed using a semi-structured questionnaire. Collected data regarding socio-demographic characteristics, knowledge of filariasis, coverage and consumption of MDA drugs were analyzed. Descriptive statistics were applied to determine coverage and compliance, with results presented alongside a 95 % confidence interval.

Results

In our study, coverage and compliance rates were 86.36 % and 91.12 % for Albendazole, while 84.12 % and 90.62 % for DEC respectively. Fear of side effects was the reason for most of the participants' non-consumption. The coverage rate was low in urban areas because of gated communities and a lack of confidence in drug distributors.

Conclusion

This recent round of MDA was effective but still fear of side effects and lack of awareness were major challenges for the compliance of MDA drugs that need to be addressed for the complete eradication of LF.

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消除淋巴丝虫病的大规模用药：印度东部以人口为基础的覆盖率和依从性研究

背景淋巴丝虫病（LF）等被忽视的热带病（NTDs）影响着全球超过10亿人，印度是其中一个重要的热点地区。尽管全球和各国都做出了努力，包括世界卫生组织（WHO）的全球消除淋巴丝虫病计划（GPELF）和印度的全国丝虫控制计划，但挑战依然存在。我们在印度奥迪沙的 Khordha 地区开展了一项研究，以评估大规模给药的覆盖率和依从性，从而改善消除淋巴丝虫病的工作。方法通过多阶段分层抽样，我们选择了 2281 名参与者作为样本，其中包括年龄在两岁或两岁以上的男性和女性。采用半结构式问卷对这些参与者进行了访谈。对收集到的有关社会人口特征、丝虫病知识、MDA 药物覆盖率和消耗量的数据进行了分析。结果在我们的研究中，阿苯达唑的覆盖率和依从率分别为 86.36 % 和 91.12 %，DEC 的覆盖率和依从率分别为 84.12 % 和 90.62 %。害怕副作用是大多数参与者不使用的原因。城市地区的覆盖率较低，原因是有门禁的社区和对药物经销商缺乏信心。结论最近这一轮的 MDA 是有效的，但对副作用的恐惧和缺乏认识仍然是遵守 MDA 药物的主要挑战，需要加以解决，以彻底根除 LF。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.