Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal Pub Date : 2024-11-20 DOI:10.1016/j.waojou.2024.101001

Sakura Sato MD , Noriyuki Yanagida MD, PhD , Ken-ichi Nagakura MD, PhD , Kyohei Takahashi MD, PhD, MPH , Magnus P. Borres MD, PhD , Motohiro Ebisawa MD, PhD

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引用次数: 0

Abstract

Background

The clinical importance of sensitization to Arachis hypogaea 6 (Ara h 6) in Japanese children remains unelucidated. We aimed to quantitatively evaluate the clinical importance of sensitization to Ara h 6 in managing peanut allergy in Japanese children.

Methods

We retrospectively analyzed the data of children with or without symptoms induced by an oral food challenge or home dosing of up to 3 g of peanuts. The specific immunoglobulin E (sIgE) levels against peanuts, Ara h 2, and Ara h 6 were quantified using an ImmunoCAP assay.

Results

We examined 273 patients aged 4.6–9.8 years (median 6.3); 189 (69%) were male, 187 (68%) had allergies to peanuts, and 43 (16%) had anaphylactic reactions to peanuts. Ara h 6 and Ara h 2 co-sensitization was observed in 224 patients (82%). Ara h 6-sIgE levels were significantly associated with the probability of allergic reactions and anaphylaxis. The 95% probability of allergic reactions to peanuts was obtained at 44.5 kU_A/L of Ara h 6-sIgE, but the 95% probability of anaphylaxis could not be calculated. A combination of Ara h 6 and Ara h 2 could not improve diagnostic accuracy for allergic reactions and anaphylaxis to peanuts.

Conclusion

Sensitization to Ara h 6 played an important role in managing peanut allergy in Japanese children, and sIgE levels provided valuable predictive information for allergic reactions to peanuts. However, the measurement of Ara h 6 did not improve the diagnostic accuracy of anaphylaxis, and Ara h 2 alone might be sufficient for clinical evaluation in peanut allergy.

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定量评估日本儿童对 Ara h 6 过敏的临床重要性

背景日本儿童对Arachis hypogaea 6（Ara h 6）过敏的临床重要性仍未得到阐明。方法我们回顾性分析了通过口服食物挑战或在家中摄入多达 3 克花生而诱发或未诱发症状的儿童的数据。结果我们对 273 名年龄在 4.6-9.8 岁（中位 6.3 岁）的患者进行了检查，其中 189 名（69%）为男性，187 名（68%）对花生过敏，43 名（16%）对花生有过敏反应。224 名患者（82%）出现了 Ara h 6 和 Ara h 2 共敏现象。Ara h 6-sIgE 水平与过敏反应和过敏性休克的概率显著相关。当 Ara h 6-sIgE 为 44.5 kUA/L 时，发生花生过敏反应的概率为 95%，但过敏性休克的 95% 概率无法计算。Ara h 6 和 Ara h 2 的组合不能提高对花生过敏反应和过敏性休克的诊断准确性。然而，Ara h 6 的测量并不能提高过敏性休克的诊断准确性，仅用 Ara h 2 可能就足以对花生过敏进行临床评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Allergy Organization Journal Immunology and Microbiology-Immunology

CiteScore

9.10

自引率

5.90%

发文量

审稿时长

9 weeks

期刊介绍： The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.