Selective and sensitive detection of glutathione with a novel fluorescein-based probe in fully aqueous media and its application in food samples

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-11-20 DOI:10.1016/j.dyepig.2024.112551

Garen Suna , Sema Topal , Erman Karakuş

引用次数: 0

Abstract

We devised a novel fluorescent probe, FL–T, bearing fluorescein and thienyl acrylic acid moiety, which was designed and synthesised to detect glutathione (GSH). Utilising micelle-catalysed cyclisation/elimination reaction, FL–T demonstrated exceptional sensitivity and operability in a fully aqueous solution, with a low limit of detection (LOD = 41.2 nM), and superior selectivity over cysteine (Cys), homocysteine (Hcy), H₂S and other analytes. Furthermore, FL–T successfully detected GSH in fruit and vegetable samples. These findings suggest that FL–T is a promising tool for detecting GSH in various environments.

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利用新型荧光素探针在全水介质中选择性灵敏检测谷胱甘肽及其在食品样品中的应用

我们设计并合成了一种新型荧光探针 FL-T，它含有荧光素和噻吩丙烯酸分子，用于检测谷胱甘肽（GSH）。利用胶束催化的环化/消除反应，FL-T 在全水溶液中表现出极高的灵敏度和可操作性，检测限低（LOD = 41.2 nM），对半胱氨酸（Cys）、同型半胱氨酸（Hcy）、H2S 和其他分析物具有极佳的选择性。此外，FL-T 还能成功检测水果和蔬菜样品中的 GSH。这些研究结果表明，FL-T 是检测各种环境中 GSH 的理想工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.