ELAVL1 governs breast cancer malignancy by regulating cell stemness

IF 4.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular cell research Pub Date : 2024-11-25 DOI:10.1016/j.bbamcr.2024.119880

Long Chen , Menglu Zhao , Linjing Liu , Tan Wang , Xue Gong , Jun Zhang

引用次数: 0

Abstract

Despite advances in understanding breast cancer (BC) molecular subtypes, the mechanisms underlying its grade of malignancy remain unclear. Our study reveals that low expression of the RNA-binding protein ELAVL1 is linked to higher-grade malignancy and poorer prognosis in malignant BC subtypes. Notably, knockdown of ELAVL1 increased the expression of key stem cell markers (CD44, SOX2, OCT4, KLF4, and NANOG) and enhanced tumorsphere formation. These findings offer new insights into BC malignancy and suggest potential improvements in prognostic assessment and treatment strategies for better patient outcomes.

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ELAVL1 通过调节细胞干性控制乳腺癌恶性程度

尽管人们对乳腺癌（BC）分子亚型的认识有所进步，但其恶性程度的内在机制仍不清楚。我们的研究发现，在恶性乳腺癌亚型中，RNA结合蛋白ELAVL1的低表达与恶性程度较高和预后较差有关。值得注意的是，ELAVL1的敲除增加了关键干细胞标志物（CD44、SOX2、OCT4、KLF4和NANOG）的表达，并增强了肿瘤球的形成。这些研究结果提供了对BC恶性肿瘤的新见解，并提出了改善预后评估和治疗策略以改善患者预后的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.