Variation in ovine serum vitamin D concentrations from late summer to early spring and during immune challenge with bacterial endotoxin

IF 1.4 3区农林科学 Q4 IMMUNOLOGY

Veterinary immunology and immunopathology Pub Date : 2024-11-22 DOI:10.1016/j.vetimm.2024.110856

Samantha Randle , Lauri Wagter-Lesperance , Samantha Dixon , Umesh K. Shandilya , Bonnie A. Mallard , Byram Bridle , Niel A. Karrow

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引用次数: 0

Abstract

Vitamin D is most known for its role in the development and maintenance of the skeletal system. However, recent studies have found that vitamin D modulates the immune system, and at sufficient levels supports optimal immune function. Previous research has examined how vitamin D levels change seasonally and during immune stress challenges in both humans and cattle, but not sheep. Our study aimed to investigate the changes in the vitamin D status of sheep throughout the year in Southern Ontario as well as in response to a bacterial endotoxin challenge. Vitamin D was found to be significantly lower in spring when compared to summer and early winter levels. No significant differences were found in vitamin D levels among any measured time points during the immune challenge, although a trending increase was found 4 hr post-challenge. Overall, this study demonstrated how vitamin D levels in sheep change throughout the year, and slightly during endotoxin challenge. Given the importance of vitamin D in regulating optimal immune function, more investigation of these changes in vitamin D levels is warranted in terms of supporting optimal immune function.

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从夏末到初春以及在细菌内毒素免疫挑战期间绵羊血清维生素 D 浓度的变化。

维生素 D 因其在骨骼系统的发育和维护方面的作用而最为人熟知。然而，最近的研究发现，维生素 D 能调节免疫系统，充足的维生素 D 能支持最佳的免疫功能。以前的研究已经考察了人和牛体内维生素 D 水平在季节性和免疫应激挑战期间的变化情况，但没有考察羊体内维生素 D 水平的变化情况。我们的研究旨在调查南安大略省绵羊全年维生素 D 状态的变化以及对细菌内毒素挑战的反应。研究发现，春季的维生素 D 水平明显低于夏季和初冬的水平。在免疫挑战过程中，各测量时间点的维生素 D 水平均无明显差异，但在挑战后 4 小时发现维生素 D 水平呈上升趋势。总之，这项研究证明了绵羊体内的维生素 D 水平在一年四季中的变化，以及在内毒素挑战期间的轻微变化。鉴于维生素 D 在调节最佳免疫功能方面的重要性，有必要对维生素 D 水平的这些变化进行更多研究，以支持最佳免疫功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary immunology and immunopathology 农林科学-免疫学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

70 days

期刊介绍： The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease. Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above. The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.