Decoding the neuroimmune axis in the atopic march: mechanisms and implications

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-11-22 DOI:10.1016/j.coi.2024.102507

Laura Brabenec , Surbhi Gupta , Tuany Eichwald , Moutih Rafei , Sebastien Talbot

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引用次数: 0

Abstract

The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions in allergic diseases are pivotal for symptom development, from anaphylaxis to chronic conditions like asthma and atopic dermatitis. This review explores the neuro-immune interplay within the atopic march, emphasizing its role in host defense, inflammation resolution, and tissue repair. We delve into the multifaceted functions of nociceptors in orchestrating type 2 immune responses and the progression of allergic disorders, focusing on key regulators such as CGRP-RAMP1 and SP-MRGPRB2/A2. Additionally, we discuss the potential of nociceptor neuron-blocking drugs to target neuro-immunity, offering the possibility of reversing the progression of the atopic march. Altogether, we underscore the need for targeted interventions to disrupt the pathological processes and enhance therapeutic outcomes at various stages of the atopic march.

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解码特应性进展中的神经免疫轴：机制与影响。

免疫系统和神经系统共同进化出了复杂的机制，能够感知环境危险，并协调作出一致的反应，以保护组织和调动宿主的防御能力。这种复杂的相互作用以共同的受体和配体为特征，影响着疾病的发病机制。从过敏性休克到哮喘和特应性皮炎等慢性疾病，过敏性疾病中的神经-免疫相互作用对症状的发展至关重要。这篇综述探讨了特应性进展过程中神经免疫的相互作用，强调了神经免疫在宿主防御、炎症消退和组织修复中的作用。我们深入探讨了痛觉感受器在协调 2 型免疫反应和过敏性疾病进展中的多方面功能，重点关注 CGRP-RAMP1 和 SP-MRGPRB2/A2 等关键调节因子。此外，我们还讨论了针对神经免疫的痛觉感受器神经元阻断药物的潜力，这为逆转特应性进展提供了可能。总之，我们强调有必要在特应性进展的各个阶段采取有针对性的干预措施，以破坏病理过程并提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.