Photoluminescent oxaliplatin loaded porous starch coated with pectin biopolymer: Design, fabrication, and controlled drug delivery

IF 5.6 1区农林科学 Q1 AGRICULTURAL ENGINEERING

Industrial Crops and Products Pub Date : 2024-11-23 DOI:10.1016/j.indcrop.2024.120124

Malihe Pooresmaeil, Hassan Namazi

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引用次数: 0

Abstract

Today’s carbohydrate-based bio-carriers have attracted more attention as drug delivery agents, so they have brilliant biocompatibility, as well as, controlled drug release potential. Considering these, the porous starch (PS) with the honeycomb network was in situ synthesized in the presence of pre-synthesized carbon dots (CDs/PS). The SEM displayed the porous structure of CDs/PS with a uniform dispersion of CDs in the polymer matrix. BET analysis obtained the diameter of the porous sites at about 37.319 nm. After oxaliplatin (OXP) loading the OXP/CDs/PS was coated with the pectin (Pec) in a green strategy ((OXP/CDs/PS)@Pec). The drug release studies displayed that the (OXP/CDs/PS)@Pec has a controlled release performance than OXP/CDs/PS in the simulated pH of oral drug delivery condition. The biocompatibility of the (CDs/PS)@Pec and its cancer cell-killing capability after drug loading were approved via MTT test. These results promoted us that the modification of OXP/CDs/PS with Pec achieves a controlled drug release profile and the fabricated system could be suggested as a new delivery system with targeted delivery potential.

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果胶生物聚合物包覆多孔淀粉的光致发光奥沙利铂：设计、制造和控制药物输送

如今，以碳水化合物为基础的生物载体作为药物递送剂受到越来越多的关注，因为它们具有出色的生物相容性和可控药物释放潜力。有鉴于此，我们在预合成碳点（CDs/PS）的存在下，原位合成了具有蜂窝状网络的多孔淀粉（PS）。扫描电子显微镜显示了 CDs/PS 的多孔结构以及 CDs 在聚合物基质中的均匀分散。BET 分析得出多孔点的直径约为 37.319 nm。载入奥沙利铂（OXP）后，OXP/CDs/PS 与果胶（Pec）进行绿色包衣（(OXP/CDs/PS)@Pec）。药物释放研究表明，在模拟 pH 值的口服给药条件下，(OXP/CDs/PS)@Pec 比 OXP/CDs/PS 具有更好的控释性能。通过 MTT 测试，(CDs/PS)@Pec 的生物相容性及其载药后的癌细胞杀伤能力得到了认可。这些结果表明，用 Pec 对 OXP/CDs/PS 进行修饰可实现药物的可控释放，所制备的系统可作为一种具有靶向给药潜力的新型给药系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Industrial Crops and Products 农林科学-农业工程

CiteScore

9.50

自引率

8.50%

发文量

1518

审稿时长

43 days

期刊介绍： Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.