Diagnosis and management of mantle cell lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Internal Medicine Journal Pub Date : 2024-11-23 DOI:10.1111/imj.16561

Allison Barraclough, Catherine Tang, Masa Lasica, Elizabeth Smyth, Melita Cirillo, Howard Mutsando, Chan Y Cheah, Matthew Ku

引用次数: 0

Abstract

Mantle cell lymphoma (MCL) is a clinically heterogeneous B-cell neoplasm with unique clinicopathological features, accounting for 5% of all non-Hodgkin lymphoma. Although for many chemoimmunotherapy can lead to durable remissions, those with poor baseline prognostic factors, namely blastoid morphology, TP53 aberrancy and Ki67 >30%, will have less durable responses to conventional therapies. With this in mind, clinical trials have focused on novel targeted therapies to improve outcomes. This review details the recent advances in the understanding of MCL biology and outlines the recommended diagnostic strategies and evidence-based approaches to treatment.

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套细胞淋巴瘤的诊断和管理：澳大利亚淋巴瘤联盟共识实践声明。

套细胞淋巴瘤（MCL）是一种临床病理特征独特的异质性 B 细胞肿瘤，占所有非霍奇金淋巴瘤的 5%。虽然对许多患者来说，化疗免疫疗法可以带来持久的缓解，但那些基线预后因素较差的患者，即胚泡形态、TP53畸变和Ki67>30%的患者，对传统疗法的持久反应较差。有鉴于此，临床试验重点关注新型靶向疗法，以改善预后。本综述详细介绍了对 MCL 生物学认识的最新进展，并概述了推荐的诊断策略和循证治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.