Medicinal plants or bioactive components with antioxidant/anti-apoptotic effects as a potential therapeutic approach in heart failure prevention and management: a literature review.

Abstract

Heart failure is described as a complicated syndrome, which is estimated that 56.2 million people were living with HF globally in 2019. Oxidative stress and apoptosis play a major role on HF development via targeting several signaling pathways in cardiac cells. This study investigated medicinal plants or their bioactive components with positive effects on HF management. In this research, keywords "heart failure," "plant," "antioxidant" or "radical scavenging," "herbal" and "apoptosis" were synchronously searched through popular databases from 1990 up to 2023. Finally, the role of oxidative stress and apoptosis in HF development was searched and related signaling pathways were investigated.