Efficacy and Safety of Combination Therapy of Microneedling Radiofrequency, In-Office and Home-Based Topical Cysteamine in Refractory Melasma: A Split Face, Vehicle-Control, Randomized Control Trial.

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2024-11-22 DOI:10.1111/jocd.16661

Ya-Wen Tsai, Cheng-Hsian Lin, Yi-Jing Lai, Tzu-Li Liu, Chau Yee Ng

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引用次数: 0

Abstract

Background: Refractory melasma remains a challenge in dermatology, necessitating the exploration of innovative treatments.

Aims: This study aims to evaluate the efficacy and safety of combining radiofrequency microneedling (RFM) with Cysteamine cream, applied both in-office and as a part of a home-care regimen, to treat refractory melasma.

Patients/methods: A vehicle-controlled, split-face trial was conducted on 30 Fitzpatrick skin types III and IV participants. Subjects received RFM and Cysteamine serum on one side of the face and RFM with saline on the contralateral side. Additionally, a random half-added Cysteamine cream was applied at home. The modified Melasma Area and Severity Index and VISIA skin analysis were used for assessment.

Results: Significant improvement in melasma severity and skin texture was noted on the sides treated with RFM and Cysteamine, including observable benefits from both in-office and home-based Cysteamine use with minimal adverse effects.

Conclusions: The combined approach of RFM with Cysteamine provides a promising and safe modality for managing refractory melasma, showing notable improvements.

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微针射频、诊室和家庭外用半胱胺联合疗法治疗难治性黄褐斑的有效性和安全性：分面、载体对照、随机对照试验。

背景：目的：本研究旨在评估将射频微针疗法（RFM）与半胱胺乳膏相结合治疗难治性黄褐斑的有效性和安全性：对30名菲茨帕特里克皮肤类型III型和IV型的受试者进行了载体对照分脸试验。受试者一侧脸部接受 RFM 和半胱胺血清治疗，另一侧脸部接受 RFM 和生理盐水治疗。此外，受试者还在家中使用了随机添加的半胱胺乳膏。采用改良的黄褐斑面积和严重程度指数以及 VISIA 皮肤分析进行评估：结果：接受 RFM 和半胱胺治疗的两侧黄褐斑严重程度和肤质均有明显改善，包括在诊室和家中使用半胱胺的明显疗效，且不良反应极小：射频消融术与半胱胺联合疗法为治疗难治性黄褐斑提供了一种前景广阔且安全的方法，并显示出显著的改善效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.