Pseudallescheria boydii infection of the bloodstream system: First reported case from China

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-11-16 DOI:10.1016/j.diagmicrobio.2024.116610

Weiwei Hou , Xuanlin Wang , Yiwen Yao , Qi Liu , Xuan Wang , Zujun Sun

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引用次数: 0

Abstract

Pseudallescheria boydii (P. boydii) is widely found in soil, sewage, decaying organic matter, and feces. Although it is associated with various clinical infections, no bloodstream infection has been reported. A 61-year-old male patient diagnosed with squamous cell carcinoma who is currently undergoing chemotherapy. The patient underwent blood culture sampling due to fever. Microscopic examination, SDA plate morphology, and mass spectrometry analysis confirmed the pathogen as P. boydii, which was further confirmed by internal transcribed spacer DNA sequencing. During treatment, empirical treatment voriconazole was significantly more effective than micafungin in treating P. boydii infection. In vitro antifungal susceptibility testing of the fungal isolates showed a very low MIC for voriconazole. In conclusion, bloodstream infections of P. boydii can occur in immunocompromised patients, and routine mass spectrometry techniques can assist in its rapid and accurate diagnosis. Additionally, empirical antifungal therapy with voriconazole remains effective in treating bloodstream infections caused by P. boydii.

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血液系统的假鲍曼不动杆菌（Pseudallescheria boydii）感染：中国首例报告病例。

Pseudallescheria boydii（P. boydii）广泛存在于土壤、污水、腐烂的有机物和粪便中。虽然它与各种临床感染有关，但还没有血液感染的报道。一名 61 岁的男性患者被诊断患有鳞状细胞癌，目前正在接受化疗。患者因发烧接受了血液培养采样。显微镜检查、SDA平板形态学和质谱分析证实病原体是波氏杆菌，内转录间隔DNA测序进一步证实了这一点。在治疗过程中，经验疗法伏立康唑治疗波菌感染的效果明显优于米卡芬净。对真菌分离株进行的体外抗真菌药敏试验显示，伏立康唑的 MIC 非常低。总之，免疫力低下的患者可能会感染波氏杆菌，常规质谱技术可帮助快速准确地诊断波氏杆菌。此外，使用伏立康唑进行经验性抗真菌治疗对治疗波氏杆菌引起的血流感染仍然有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.