Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses.

IF 5.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

European Journal of Endocrinology Pub Date : 2024-10-29 DOI:10.1093/ejendo/lvae133

Nick Narinx, Ross J Marriott, Kevin Murray, Robert J Adams, Christie M Ballantyne, Douglas C Bauer, Shalender Bhasin, Mary L Biggs, Peggy M Cawthon, David J Couper, Adrian S Dobs, Leon Flicker, Graeme J Hankey, Anke Hannemann, Robin Wilkening, Sean A Martin, Alvin M Matsumoto, Claes Ohlsson, Terence W O'Neill, Eric S Orwoll, Molly M Shores, Antje Steveling, Thomas G Travison, Gary A Wittert, Frederick C W Wu, Leen Antonio, Dirk Vanderschueren, Bu B Yeap

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引用次数: 0

Abstract

Objective: Sociodemographic, lifestyle, and medical variables influence total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations. The relationship between these factors and "free" T remains unclear. We examined 21 sociodemographic, lifestyle, and medical predictors influencing calculated free T (cFT) in community-dwelling men across ages.

Design: This is a cross-sectional analysis in 20 631 participants in the Androgens in Men Study.

Methods: Individual participant data (IPD) were provided by 9 cohorts. Total T was determined using mass spectrometry, SHBG using immunoassays, and cFT using the Vermeulen formula. Associations were analyzed using 2-stage random effects IPD meta-analyses.

Results: Cohort median ages ranged from 40 to 76 years and median cFT concentrations from 174.3 to 422.8 pmol/L. In men aged 17-99 years, there was a linear inverse association of cFT with age (-57.2 pmol/L [95% confidence interval, -69.4, -44.9] per 1 SD increase in age). Calculated free T increased with increasing baseline body mass index (BMI) among men with BMI < 23.6 kg/m2, but decreased among men with BMI > 23.6 kg/m2 (-24.7 pmol/L [-29.1, -20.3] per 1 SD increase in the 25.4-29.6 kg/m2 BMI range). Calculated free T was lower in younger men, who were married or in a de facto relationship (-18.4 pmol/L [-27.6, -9.3]) and in men who formerly smoked (-5.7 pmol/L [-8.9, -2.6]), were in poor general health (-14.0 pmol/L [-20.1, -7.8]), and had diabetes (-19.6 pmol/L [-23.0, -16.3]), cardiovascular disease (-5.8 pmol/L [-8.3, -3.2]), or cancer (-19.2 pmol/L [-24.4, -14.1]).

Conclusions: Calculated free T was most prominently associated with age and BMI. The linear, inverse association with age, nonlinear association with BMI, and presence of diabetes, cancer, and sociodemographic factors should be considered when interpreting cFT values.

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与计算出的男性游离睾酮浓度相关的社会人口、生活方式和医疗因素：个体参与者数据荟萃分析。

目的：社会人口、生活方式和医疗变量会影响总睾酮（T）和性激素结合球蛋白（SHBG）的浓度。这些因素与 "游离 "睾酮之间的关系仍不清楚。我们研究了影响各年龄段社区男性计算游离睾酮（cFT）的 21 个社会人口、生活方式和医疗预测因素：这是一项横断面分析，研究对象是男性雄激素研究的 20 631 名参与者：方法：9 个队列提供了参与者的个人数据（IPD）。采用质谱法测定总T，采用免疫测定法测定SHBG，采用Vermeulen公式测定cFT。采用两阶段随机效应 IPD 元分析对相关性进行了分析：群组的中位年龄为 40 至 76 岁，中位 cFT 浓度为 174.3 至 422.8 pmol/L。在 17-99 岁的男性中，cFT 与年龄呈线性负相关（年龄每增加 1 SD，cFT 浓度为-57.2 pmol/L [95% 置信区间，-69.4，-44.9]）。在 BMI < 23.6 kg/m2 的男性中，计算游离 T 随基线体重指数（BMI）的增加而增加，但在 BMI > 23.6 kg/m2 的男性中，计算游离 T 随基线体重指数（BMI）的增加而减少（在 25.4-29.6 kg/m2 的 BMI 范围内，每增加 1 个标准差，游离 T 为-24.7 pmol/L [-29.1, -20.3]）。已婚或有事实婚姻关系的年轻男性（-18.4 pmol/L [-27.6，-9.3]）、以前吸烟的男性（-5.7 pmol/L [-8.9，-2.6]）、一般健康状况较差的男性（-14.0 pmol/L [-20.1, -7.8]）、患有糖尿病（-19.6 pmol/L [-23.0, -16.3]）、心血管疾病（-5.8 pmol/L [-8.3, -3.2]）或癌症（-19.2 pmol/L [-24.4, -14.1]）的男性：计算游离 T 与年龄和体重指数的关系最为显著。在解释 cFT 值时，应考虑与年龄的线性反比关系、与体重指数的非线性关系以及是否存在糖尿病、癌症和社会人口因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

9.80

自引率

3.40%

发文量

354

审稿时长

1 months

期刊介绍： European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.