A 3D Pancreatic Cancer Model with Integrated Optical Sensors for Noninvasive Metabolism Monitoring and Drug Screening (Adv. Healthcare Mater. 29/2024)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2024-11-21 DOI:10.1002/adhm.202470188

Anna Chiara Siciliano, Stefania Forciniti, Valentina Onesto, Helena Iuele, Donatella Delle Cave, Federica Carnevali, Giuseppe Gigli, Enza Lonardo, Loretta L. del Mercato

引用次数: 0

Abstract

3D Sensing Matrixes

Three-dimensional hydrogels integrating sensors support co-culture of tumor and stromal cells, replicating their metabolic interactions. This hybrid matrix, using live cell imaging and computational analysis, enables non-invasive single-cell metabolism monitoring and drug testing, advancing drug screening and personalized medicine. More details can be found in article 2401138 by Loretta L. del Mercato and co-workers.

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用于无创代谢监测和药物筛选的集成光学传感器三维胰腺癌模型（Adv. Healthcare Mater.）

三维传感基质集成传感器的三维水凝胶支持肿瘤细胞和基质细胞的共培养，复制它们之间的代谢相互作用。这种混合基质利用活细胞成像和计算分析，实现了无创单细胞代谢监测和药物测试，推动了药物筛选和个性化医疗的发展。更多详情，请参阅 Loretta L. del Mercato 及其合作者撰写的文章 2401138。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.