Using tumor DNA methylomes to predict cancer metastasis to the brain

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2024-11-22 DOI:10.1038/s41591-024-03402-y

引用次数: 0

Abstract

Metastatic spread of cancer to the brain has a devastating effect on patient outcomes, yet identifying patients who will develop brain metastases is difficult in current clinical practice. We show that DNA methylation signatures from lung adenocarcinomas can accurately predict which patients are at risk of metastasis to the brain, which could transform future cancer care.

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利用肿瘤 DNA 甲基组预测癌症向大脑的转移

癌症向大脑的转移扩散对患者的预后具有破坏性影响，但在目前的临床实践中，很难确定哪些患者会发生脑转移。我们的研究表明，肺腺癌的DNA甲基化特征可以准确预测哪些患者有向大脑转移的风险，这将改变未来的癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.