Proteome-wide CETSA reveals new step in apoptosis control.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-11-19 DOI:10.1016/j.tcb.2024.11.001

Inna N Lavrik, Nikita V Ivanisenko

引用次数: 0

Abstract

Apoptosis, a well-established program of cell death, is fundamental to all multicellular organisms. Recent studies of apoptosis initiation events using proteome-wide cellular thermal shift assay (CETSA) have revealed a novel regulatory mechanism involving the cleavage of nuclear substrates. This finding suggests a previously unrecognized amplification step in apoptosis occurring within the nucleus.

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全蛋白质组 CETSA 揭示了细胞凋亡控制的新步骤。

细胞凋亡是一种成熟的细胞死亡程序，是所有多细胞生物的基础。最近利用全蛋白质组细胞热转移测定法（CETSA）对细胞凋亡启动事件进行的研究揭示了一种涉及核底物裂解的新型调控机制。这一发现表明，细胞凋亡的放大步骤发生在细胞核内，而这一步骤以前未被认识到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.