The new perspective of Alzheimer's Disease Research: Mechanism and therapeutic strategy of neuronal senescence

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-19 DOI:10.1016/j.arr.2024.102593

Qianqian Niu , Danjie Li , Jiayin Zhang , Zhengji Piao , Bo Xu , Yuting Xi , Nik Nur Syazni Nik Mohamed Kamal , Vuanghao Lim , Peng Li , Yaling Yin

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Abstract

Alzheimer's disease (AD), commonly known as senile dementia, is a neurodegenerative disease with insidious onset and gradually worsening course. The brain is particularly sensitive to senescence, and neuronal senescence is an important risk factor for the occurrence of AD. However, the exact pathogenesis between neuronal senescence and AD has not been fully elucidated so far. Neuronal senescence is characterized by the permanent stagnation of the cell cycle, and the changes in its structure, function, and microenvironment are closely related to the pathogenesis and progression of AD. In recent years, studies such as the Aβ cascade hypothesis and Tau protein phosphorylation have provided new strategies for the therapy of AD, but due to the complexity of the etiology of AD, there are still no effective treatment measures. This article aims to deeply analyze the pathogenesis between AD and neuronal senescence, and sort out various existing therapeutic methods, to provide new ideas and references for the clinical treatment of AD.

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阿尔茨海默病研究的新视角：神经元衰老的机制与治疗策略。

阿尔茨海默病（AD）俗称老年痴呆症，是一种起病隐匿、病程逐渐恶化的神经退行性疾病。大脑对衰老特别敏感，神经元衰老是阿尔茨海默病发生的重要风险因素。然而，神经元衰老与渐冻症之间的确切发病机制至今尚未完全阐明。神经元衰老的特征是细胞周期的永久性停滞，其结构、功能和微环境的变化与AD的发病和进展密切相关。近年来，Aβ级联假说、Tau蛋白磷酸化等研究为AD的治疗提供了新的策略，但由于AD病因的复杂性，目前仍没有有效的治疗措施。本文旨在深入分析AD与神经元衰老的发病机制，梳理现有的各种治疗方法，为AD的临床治疗提供新的思路和参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.