TNF-expressing CD1d+ monocytes are associated with the activation of CD4- CD8- T cells in patients with Chagas cardiomyopathy.

IF 1.8 4区医学 Q2 PARASITOLOGY

Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.1590/0037-8682-0181-2024

Carolina Cattoni Koh, Teresiama Velikkakam, Eula Graciele Amorim Neves, Nayara Ingrid Medeiros, Juliana Assis Gomes, Silvana de Araújo Silva, Kenneth John Gollob, Maria do Carmo Pereira Nunes, Walderez Ornelas Dutra

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引用次数: 0

Abstract

Background: Chagas disease cardiomyopathy is characterized by intense immune activation, with double-negative (DN) T cells as key producers of inflammatory cytokines. CD1d is an antigen-presenting molecule involved in the activation of DN T cells.

Methods: We characterized CD1d+ monocytes from patients with cardiac (CARD) and indeterminate (IND) disease using flow cytometry.

Results: CARD CD1d+ monocytes exhibited higher expression of TNF, TNF-receptor, PDL-1, and Fas-L compared to those from IND. These monocytes correlated with TNF expression by DN T-cells in CARD but not in IND.

Conclusions: CD1d+ monocytes from CARD are inflammatory and associated with DN T-cell activation, confirming that CD1d is a target for modulating inflammation in Chagas cardiomyopathy.

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表达 TNF 的 CD1d+ 单核细胞与恰加斯病心肌病患者 CD4- CD8- T 细胞的活化有关。

背景：恰加斯病心肌病的特征是强烈的免疫激活，双阴性（DN）T细胞是炎症细胞因子的主要产生者。CD1d 是一种参与激活 DN T 细胞的抗原递呈分子：我们使用流式细胞术鉴定了心脏疾病（CARD）和不确定疾病（IND）患者的 CD1d+ 单核细胞：结果：与 IND 患者相比，CARD CD1d+ 单核细胞的 TNF、TNF 受体、PDL-1 和 Fas-L 表达量更高。这些单核细胞与 CARD 的 DN T 细胞表达的 TNF 相关，但与 IND 的 DN T 细胞表达的 TNF 无关：结论：来自 CARD 的 CD1d+ 单核细胞具有炎症性并与 DN T 细胞活化相关，这证实 CD1d 是恰加斯心肌病炎症调节的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista da Sociedade Brasileira de Medicina Tropical 医学-热带医学

CiteScore

3.40

自引率

10.00%

发文量

195

审稿时长

3-8 weeks

期刊介绍： The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.