Platelet factor 4 immune disease: medical emergencies that look like heparin-induced thrombocytopenia.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Internal Medicine Journal Pub Date : 2024-11-20 DOI:10.1111/imj.16546

Ashwini Bennett, Phil Y Choi, Chee Wee Tan

引用次数: 0

Abstract

Heparin-induced thrombocytopenia (HIT) is a serious adverse reaction to heparin. Other HIT-like syndromes are increasingly recognised, mediated by antibodies binding to platelet factor 4, with or without identifiable polyanions. The history of heparin exposure is atypical for classical HIT and standard HIT laboratory tests may be negative. This manuscript describes subtypes of HIT-like syndromes and highlights practical tips for diagnosis and therapy.

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血小板因子 4 免疫疾病：看似肝素诱导的血小板减少症的医疗急症。

肝素诱导的血小板减少症（HIT）是肝素的一种严重不良反应。其他类似 HIT 的综合征也日益得到认可，这些综合征由与血小板因子 4 结合的抗体介导，伴有或不伴有可识别的多聚阳离子。经典 HIT 的肝素暴露史并不典型，标准的 HIT 实验室检测可能呈阴性。本手稿描述了 HIT-like 综合征的亚型，并重点介绍了诊断和治疗的实用技巧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.