Quantifying the Reversibility of Clofazimine-induced Pigmentation in a Patient with Mycobacterium abscessus Pulmonary Disease.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2024-11-21 DOI:10.2169/internalmedicine.4498-24

Masashi Ito, Fumiya Watanabe, Koji Furuuchi, Keiji Fujiwara, Tatsuya Kodama, Takashi Ohe, Yoshiaki Tanaka, Takashi Yoshiyama, Ken Ohta, Kozo Morimoto

引用次数: 0

Abstract

A 45-year-old woman with Mycobacterium abscessus pulmonary disease was treated with multidrug therapy, including clofazimine, at Fukujuji Hospital. Six months after clofazimine initiation, the treatment was discontinued at the patient's request due to hyperpigmentation. Pigmentation is a critical side effect of clofazimine. We quantified clofazimine-induced pigmentation on her face using NeoVoirI^® and measured the serum concentration of clofazimine during the administration period. The patient's skin tone score closely correlated with the serum concentration of clofazimine. However, 14 months after the discontinuation of clofazimine, clofazimine-induced pigmentation was still not completely resolved.

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量化脓肿分枝杆菌肺病患者氯唑明诱发色素沉着的可逆性

一名 45 岁的女性患者患有脓肿分枝杆菌肺病，在福寺医院接受了包括氯法齐明在内的多种药物治疗。开始使用氯法齐明 6 个月后，由于出现色素沉着，在患者的要求下停止了治疗。色素沉着是氯法齐明的一个重要副作用。我们使用 NeoVoirI® 对氯唑明引起的面部色素沉着进行了量化，并测量了用药期间氯唑明的血清浓度。患者的肤色评分与血清中氯法齐明的浓度密切相关。然而，在停用氯唑明 14 个月后，氯唑明引起的色素沉着仍未完全消除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.