Positive Antiganglioside Antibodies in a Patient with Primary Diffuse Large B-cell Lymphoma of the Central Nervous System.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2024-11-21 DOI:10.2169/internalmedicine.2326-23

Ryoji Nishi, Haruki Koike, Tomoya Maekawa, Yoshitaka Nakamura, Yohei Kawade, Takashi Tsujiuchi, Masasuke Ohno, Yuki Fukami, Masahisa Katsuno, Takafumi Sagisaka

引用次数: 0

Abstract

Up to one-third of lymphoma cases involve the nervous system. Miller-Fisher syndrome (MFS) associated with lymphoma is extremely rare. We herein report a case of primary central nervous system lymphoma initially mimicking MFS in a 70-year-old man who presented with subacute unsteady gait and diplopia. A neurological examination revealed unilateral ophthalmoplegia, ataxia, and areflexia. The patient tested positive for anti-GQ1b antibodies, so MFS was initially suspected. However, the progression extended over one month. Subsequently, disturbance of consciousness was observed. Cranial magnetic resonance imaging revealed lesions in the periventricular fourth ventricle, and a brain biopsy indicated diffuse large B-cell lymphoma.

查看原文本刊更多论文

中枢神经系统原发性弥漫大 B 细胞淋巴瘤患者的抗神经节苷脂抗体阳性。

多达三分之一的淋巴瘤病例涉及神经系统。与淋巴瘤相关的米勒-费舍尔综合征（MFS）极为罕见。我们在此报告了一例原发性中枢神经系统淋巴瘤病例，患者最初表现为亚急性步态不稳和复视。神经系统检查发现单侧眼球震颤、共济失调和肢体瘫痪。患者的抗 GQ1b 抗体检测呈阳性，因此最初怀疑是 MFS。然而，病情发展持续了一个月。随后，患者出现意识障碍。头颅磁共振成像显示第四脑室周围有病变，脑活检显示为弥漫大B细胞淋巴瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.