Is choline kinase alpha a drug target for obesity?

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1492753

Juan Carlos Lacal, Salam A Ibrahim, Tahl Zimmerman

引用次数: 0

Abstract

Choline kinase alpha (ChoKα) is a therapeutic target being developed for a variety of diseases, from cancer to rheumatoid arthritis and from parasites to bacterial infections. Nevertheless, the therapeutic potential of this drug target seems not exhausted and may end up as a possible solution for a larger variety of conditions. Here we present our working model for how ChoKα could play a role in obesity and for how drugs being developed as therapeutics for other diseases using ChoKα as a target, could be repurposed as prophylactic treatments for obesity. We also present preliminary observations in support of our model.

查看原文本刊更多论文

胆碱激酶α是治疗肥胖症的药物靶点吗？

从癌症到类风湿性关节炎，从寄生虫到细菌感染，胆碱激酶α（ChoKα）是目前正在开发的治疗各种疾病的靶点。然而，这一药物靶点的治疗潜力似乎还没有被挖掘殆尽，最终可能会成为更多疾病的解决方案。在此，我们介绍了我们的工作模型，即 ChoKα 如何在肥胖症中发挥作用，以及正在开发的以 ChoKα 为靶点治疗其他疾病的药物如何被重新用作肥胖症的预防性治疗。我们还提出了支持我们模型的初步观察结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.