Patterns of subsequent cancer incidence over time in patients with breast cancer.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-11-21 DOI:10.1158/1055-9965.EPI-24-1009

Zhengyi Deng, Kala Visvanathan

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引用次数: 0

Abstract

Background: Breast cancer survivors face a higher risk of subsequent primary cancers. This study investigated the patterns of subsequent cancer risk according to time since breast cancer diagnosis.

Methods: Using data from the Surveillance, Epidemiology, and End Results program (2000-2018), we identified a cohort of 771,681 breast cancer survivors. Standard incidence ratios (SIR) were calculated by comparing the observed to the expected number of subsequent cancers over different follow-up periods since breast cancer diagnosis. Analyses were conducted for multiple cancer types, stratified by hormone receptor (HR) status and treatment of the first breast cancer, age, and race/ethnicity.

Results: Survivors experienced a 16% increased risk of subsequent cancer with the SIR continuing to increase with longer follow-up (SIR=1.04, 1.22, and 1.31 for 12-59, 60-119, and ≥120 months). This trend was driven primarily by a subsequent breast cancer, particularly among women <50 years, those with initial HR-negative cancer, and racial/ethnic minorities. The patterns of subsequent non-breast cancer risk varied by type. An early-onset and sustained increased risk was observed for subsequent leukemia, thyroid, soft tissue, melanoma, pancreas, and uterine cancer. A delayed increased risk was observed for subsequent esophagus, ovarian, oral cavity/pharynx, and lung cancer, while for small intestine, stomach, kidney, and colorectal cancer there was a decrease after an initial increased risk.

Conclusions: Patterns in subsequent cancer risk since breast cancer diagnosis differ by cancer type and characteristics of the first breast cancer.

Impact: These findings can inform etiology and tailored approaches to screening and prevention of subsequent cancers.

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乳腺癌患者随时间推移的后续癌症发病率模式。

背景：乳腺癌幸存者罹患原发性癌症的风险较高。本研究根据乳腺癌确诊后的时间调查了后续癌症风险的模式：利用监测、流行病学和最终结果项目（2000-2018 年）的数据，我们确定了一个包含 771,681 名乳腺癌幸存者的队列。通过比较乳腺癌确诊后不同随访期内观察到的后续癌症数量与预期数量，计算出标准发病率比（SIR）。对多种癌症类型进行了分析，并根据激素受体（HR）状态和首次乳腺癌的治疗方法、年龄以及种族/民族进行了分层：结果：幸存者罹患后续癌症的风险增加了 16%，随访时间越长，SIR 越高（12-59 个月、60-119 个月和≥120 个月的 SIR 分别为 1.04、1.22 和 1.31）。这一趋势主要是由继发乳腺癌引起的，尤其是在女性结论中：乳腺癌确诊后的后续癌症风险模式因癌症类型和首次乳腺癌的特征而异：影响：这些发现可为病因学以及筛查和预防后续癌症的定制方法提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.