Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity.

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2024-11-21 DOI:10.1128/aac.00988-24

Nathan P Wiederhold, Hoja P Patterson, Dora Ferrer, Victor Garcia, George R Thompson, Thomas F Patterson

引用次数: 0

Abstract

We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).

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Olorofim 对球孢子菌具有体外活性，包括对氟康唑活性降低的分离株。

我们评估了 Olorofim 对球孢子菌的体外活性。奥罗菲姆对所有受试分离菌株都表现出了很强的体外活性，其最低抑菌浓度（MIC）范围≤0.008-0.06 µg/mL，几何平均MIC为0.010 µg/mL。对于氟康唑 MIC 值较高（≥16 µg/mL）的分离菌株，包括 MIC 值≥32 µg/mL（奥洛菲 MIC 值范围≤0.008-0.06 µg/mL，几何平均 MIC 值分别为≤0.009 和≤0.013 µg/mL）的菌株，也能保持这种活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.