A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-11-21 DOI:10.1111/jdi.14343

Amin Mansoori, Mina Nosrati, Mohsen Dorchin, Fatemeh Mohammadyari, Elahe Derakhshan-Nezhad, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

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Abstract

Background: Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low-income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index which is derived from fasting state. In this study we aimed to compare the accuracy of with CHG index and triglycerides (TG) and glucose levels (TyG) as surrogates of type 2 diabetes mellitus.

Methods: A total of 9,704 individuals between 35 and 65 years of age were recruited as part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. They were categorized into two groups, those with and without type 2 diabetes mellitus. The cut-off in groups to detection of type 2 diabetes mellitus was fasting blood glucose ≥126 mg/dL in blood sample. Receiver operating characteristic (ROC) curve analysis was used to establish the cut-off of indices to evaluate the sensitivity and specificity of them.

Results: The best cut-off of CHG index for diagnosis of type 2 diabetes mellitus was 5.57 which was associated with a sensitivity of 70.38% and specificity of 89.82% values. This was in comparison to the TyG index. LR+ CHG index was 6.91 compared to 3.47 for the TyG index and the AUC of CHG index was 0.864 (0.857, 0.871) compared with 0.825 (0.818, 0.833) for the TyG index. This indicates that the CHG index has a higher efficiency value to diagnose of type 2 diabetes mellitus.

Conclusions: The CHG index could be useful for the detection of type 2 diabetes mellitus.

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诊断 2 型糖尿病的新指标：胆固醇、高密度脂蛋白和葡萄糖（CHG）指数。

背景：2 型糖尿病的金标准方法价格昂贵，因此不适用于低收入国家的大规模研究。我们研究了用于诊断 2 型糖尿病的总胆固醇、高密度脂蛋白（HDL）和血糖（CHG）指数，该指数来自空腹状态。本研究旨在比较 CHG 指数与甘油三酯（TG）和葡萄糖水平（TyG）作为 2 型糖尿病替代指标的准确性：马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究共招募了 9704 名 35 至 65 岁的患者。他们被分为两组，即患有和未患有 2 型糖尿病的人群。各组检测 2 型糖尿病的临界值为血样中空腹血糖≥126 毫克/分升。采用接收者操作特征曲线（ROC）分析法确定指数的临界值，以评估其灵敏度和特异性：诊断 2 型糖尿病的最佳 CHG 指数临界值为 5.57，其敏感性为 70.38%，特异性为 89.82%。这是与 TyG 指数相比得出的结果。LR+ CHG 指数为 6.91，而 TyG 指数为 3.47；CHG 指数的 AUC 为 0.864 (0.857, 0.871)，而 TyG 指数为 0.825 (0.818, 0.833)。这表明 CHG 指数在诊断 2 型糖尿病方面具有更高的效率值：结论：CHG指数可用于检测2型糖尿病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).