Aruna N. Patil, Shweta S. Patil, Amit A. Kamble, Suvarta D. Kharade, Dipak S. Gaikwad
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引用次数: 0
Abstract
An eco-benign, efficient, cost-effective, high energy-efficient method has been devised for synthesizing diamino-4-phenyl-3,5-dicyano-2-pyridone through a one-pot, three-component reaction. The technique involves the reaction of aryl aldehyde, malononitrile, and cyanoacetic acid hydrazide at 60 °C, utilizing water extract of incense stick ash as a catalyst and recyclable medium. Utilizing water extract as a solvent and catalyst reduces dependency on hazardous and harmful solvents, which are typically non-renewable and contribute to unfavorable emissions. The used incense stick ash was characterized by XRD and EDS analysis. The ash extract consists of metal oxides and carbonates which are basic and can act as catalysts. The reaction proceeds through the Knoevengel reaction, subsequent Michael addition and followed by intramolecular cyclization to furnish N-amino-2-pyridone in good to excellent yields. The structures of the synthesized compounds were confirmed based on IR, 1H, and 13C NMR spectral data analysis.
期刊介绍：
Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry.
The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.
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