Zoonotic Potential of Chronic Wasting Disease After Adaptation in Intermediate Species

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-11-20 DOI:10.3201/eid3012.240536

Tomás Barrio, Sylvie L. Benestad, Jean-Yves Douet, Alvina Huor, Séverine Lugan, Naïma Aron, Hervé Cassard, Juan Carlos Espinosa, Alicia Otero, Rosa Bolea, Juan María Torres, Olivier Andréoletti

引用次数: 0

Abstract

Chronic wasting disease (CWD) is an emerging disease in Europe. We report an increase in interspecies transmission capacity and zoonotic potential of a moose CWD isolate from Europe after passage in an ovine prion protein–expressing host. Those results indicated some CWD prions could acquire enhanced zoonotic properties following adaptation in an intermediate species.

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慢性消耗性疾病在中间物种适应后的人畜共患可能性

慢性消耗性疾病（CWD）是欧洲一种新出现的疾病。我们报告了欧洲的一种驼鹿慢性消耗性疾病分离物在通过绵羊朊病毒蛋白表达宿主后，其种间传播能力和人畜共患病潜力都有所提高。这些结果表明，一些化武狂犬病朊病毒在中间物种中适应后，可获得更强的人畜共患病特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.