Acid-Responsive Liposomal Nanodrug with promoted Tumor Penetration for Photoacoustic Imaging-Guided Sonodynamic Therapy

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-11-21 DOI:10.1039/d4cc05043f

Xiangli Li, Wen-Jing Tang, Wei Wang, Shuzhen Yue, Huiqin Yao, Jun-Jie Zhu

引用次数: 0

Abstract

Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O₂)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O₂-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.

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促进肿瘤穿透的酸响应脂质体纳米药物用于光声成像引导的声动力疗法

本文开发了一种酸响应脂质体纳米药物，用于光声（PA）成像引导的氧气（O2）依赖性声动力疗法（SDT）。这种脂质体纳米药物具有以下几个优点：(i) 在超声波照射下，它能促进不依赖于氧气的烷基自由基的生成；(ii) 它具有酸响应电荷还原性，能增强肿瘤穿透力；(iii) 它能进行活化 PA 成像以获得治疗反馈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.