Decoding retrons: Breakthroughs in RT-DNA production and genome editing

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-11-21 DOI:10.1016/j.chembiol.2024.10.011

Wenqian Liu , Yingjia Pan , Yu Zhang , Chang Dong , Lei Huang , Jiazhang Lian

引用次数: 0

Abstract

Retrons are notable for their anti-phage defense functions and genome engineering applications. However, only a few retrons have been well characterized. In the August issue of Nature Biotechnology, Khan et al.¹ present hundreds of experimentally studied retrons, which are critical for bacterial immunity research and retron-based genome engineering technologies.

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解码 RT：RT-DNA 生产和基因组编辑方面的突破

视网膜因其抗噬菌体防御功能和基因组工程应用而备受关注。然而，只有少数 retrons 得到了很好的表征。在 8 月份的《自然-生物技术》（Nature Biotechnology）杂志上，Khan 等人1 介绍了数百个经过实验研究的 retrons，这对细菌免疫研究和基于 retron 的基因组工程技术至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.