Drug monitoring was conducted for rifapentine among people with HIV receiving dolutegravir containing antiretroviral therapy and latent tuberculosis treatment.

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Microbiology Immunology and Infection Pub Date : 2024-11-14 DOI:10.1016/j.jmii.2024.11.002

Jeng-Hung Chen, Yi-Chun Lin, Cheng-Pin Chen, Shu-Hsing Cheng, Hui-Chun Hu, Hsiu-Wen Yeh, Hui-Ting Shieh, Chien-Yu Cheng

引用次数: 0

Abstract

The proportion of trough plasma concentration of dolutegravir (DTG) above protein adjusted 90 % inhibition concentration (IC90) (0.064 mg/L) was 98.1 % across all visits during the twelve doses of once-weekly rifapentine and isoniazid (3HP) in people with HIV (PWH). Furthermore, the participants maintained a high rate of HIV viral suppression (98 %) within 6 months after completing 3HP.

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对接受含有多罗替拉韦的抗逆转录病毒疗法和潜伏肺结核治疗的艾滋病毒感染者中的利福喷丁进行了药物监测。

在对艾滋病病毒感染者（PWH）进行十二次每周一次的利福喷丁和异烟肼（3HP）治疗期间，多鲁曲韦（DTG）血浆谷浓度高于蛋白调整90%抑制浓度（IC90）（0.064 mg/L）的比例在所有访问中均为98.1%。此外，参与者在完成 3HP 后的 6 个月内保持了较高的 HIV 病毒抑制率（98%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

15.90

自引率

5.40%

发文量

159

审稿时长

67 days

期刊介绍： Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.