Protection of lutein against the neurotoxicity of cisplatin in the rat brain

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2024-11-14 DOI:10.1016/j.tice.2024.102609

Sedat Bilgiç , İbrahim Aktaş , Ahmad Yahyazadeh

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引用次数: 0

Abstract

One of the biggest problems of cancer treatment is the harmful effects of these drugs on the healthy tissues and organs of the organism. Our study aims to determine the possible protective effects of Lutein (L) against the toxicity of the pharmacological substance Cisplatin (CS), which is used in the treatment of cancer, in the brain of rats, through biochemical and histopathological tests. In our study, lutein (L) (100 mg/kg, orally) was administered for brain toxicity caused by CS (10 mg/kg, intraperitoneal (i.p.)). The study was completed in 7 days with a total of 28 rats from 4 groups, each consisting of 7 subjects. Control, L, CS and CS + L. A decrease in MDA level and an increase in CAT, GSH and SOD levels were observed in the CS + L group compared to the CS group. In histopathological examinations, no significant pathological changes were detected in the cerebrum, while degeneration in Purkinje cells and apoptosis in neurons in the molecular and granular layers in the cerebellum were detected. It is understood from the study that L alleviates the results of oxidative stress, increases antioxidant functions and positively supports brain functions. It also demonstrates the ability of L to prevent CS-induced brain damage. Ultimately, L appears to be a applicable pharmacological agent in this damage.

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叶黄素对大鼠大脑顺铂神经毒性的保护作用

癌症治疗的最大问题之一是这些药物对机体健康组织和器官的有害影响。我们的研究旨在通过生化和组织病理学测试，确定叶黄素（L）对治疗癌症的药物顺铂（CS）在大鼠大脑中的毒性可能具有的保护作用。在我们的研究中，叶黄素（L）（100 毫克/千克，口服）用于治疗 CS（10 毫克/千克，腹腔注射）引起的脑部毒性。研究在 7 天内完成，4 组共 28 只大鼠，每组 7 人。与 CS 组相比，CS + L 组的 MDA 水平下降，CAT、GSH 和 SOD 水平上升。在组织病理学检查中，未发现大脑有明显的病理变化，但发现小脑分子层和颗粒层的浦肯野细胞变性和神经元凋亡。研究表明，L 能缓解氧化应激的结果，增强抗氧化功能，对大脑功能有积极的支持作用。它还证明了 L 能够预防 CS 引起的脑损伤。最终，L 似乎是一种适用于这种损伤的药剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.