Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke.

IF 3.8 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Kelly C Martin, Anna Seydell-Greenwald, Peter E Turkeltaub, Catherine E Chambers, William D Gaillard, Elissa L Newport
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Abstract

In healthy adults different language abilities-sentence processing versus emotional prosody-are supported by the left (LH) versus the right hemisphere (RH), respectively. However, after LH stroke in infancy, RH regions often support both abilities with normal outcomes. This finding raises an important question: How does the functional map of RH regions change to support both emotional prosody and also typically left-lateralized language functions after an early LH stroke? Does sentence processing simply become reflected into RH frontotemporal regions and overlap with emotional prosody processing? Or do these functions overlap less than would be expected with simple mirroring? In the current work we used task fMRI to examine precisely how sentence processing and emotional prosody processing are both organized in the intact RH of individuals who suffered a large LH perinatal arterial ischemic stroke (LHPS participants). We evaluated the activation of two fMRI tasks that probed auditory sentence processing and emotional prosody processing, comparing the overlap for these two functions in the RH of individuals with perinatal stroke with the symmetry of these functions in the LH and RH of their healthy siblings. We found less activation overlap in the RH of individuals with LH perinatal stroke than would be expected if both functions retained their typical spatial layout, suggesting that their spatial segregation may be an important feature of a functioning language system.

围产期中风后,右侧脐周皮层的句子处理和情感拟声功能分区。
在健康的成年人中,左半球(LH)和右半球(RH)分别支持不同的语言能力--句子处理和情感表达。然而,婴儿期左半球中风后,右半球区域往往支持这两种能力,且结果正常。这一发现提出了一个重要问题:早期 LH 中风后,RH 区域的功能图谱是如何变化以同时支持情感拟声和典型的左侧语言功能的?句子处理是否简单地反映到 RH 额颞区并与情感拟声处理重叠?还是这些功能的重叠程度低于简单镜像的预期?在当前的研究中,我们使用任务 fMRI 准确地研究了句子处理和情感拟声处理是如何在遭受大面积 LH 围产期动脉缺血性中风的个体(LHPS 参与者)的完整 RH 中组织起来的。我们评估了两项探查听觉句子处理和情感拟声处理的 fMRI 任务的激活情况,比较了围产期中风患者 RH 中这两项功能的重叠情况及其健康兄弟姐妹 LH 和 RH 中这两项功能的对称性。我们发现,如果围产期中风患者的左侧大脑和右侧大脑的这两种功能都保留了典型的空间布局,那么围产期中风患者的左侧大脑和右侧大脑中这两种功能的激活重叠就会比预期的要少,这表明这两种功能的空间分离可能是正常语言系统的一个重要特征。
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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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