Assessment of anterior scleral thickness in myopes and emmetropes using anterior segment optical coherence tomography.

IF 1.8 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Vision Pub Date : 2024-04-22 eCollection Date: 2024-01-01

Zhi-Liang Li, Qi Xiong, Shun-Cheng Cai, Yue Fu, Yu-Ting Li, Xiao-Min Chen, Lin Yang, Min Ke

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引用次数: 0

Abstract

Purpose: To investigate the differences in anterior scleral thickness (AST) among the refractive statuses of Chinese adults aged 18-35.

Methods: This study recruited 170 Chinese participants (mean age, 24.06 ± 2.78 years), including myopes (spherical equivalent refraction [SER] -1.00 to -12.75 diopters [D]; n = 134), emmetropes (SER ± 0.75 D; n = 36), and AST (superior, inferior, nasal, and temporal), which were investigated via swept-source optical coherence tomography. Semiautomated custom-designed software measured the scleral thickness from the scleral spur to 5 mm along four meridians.

Results: The mean axial length and spherical equivalent refractive error were 25.12 ± 1.44 mm and -3.93 ± 3.09 D, respectively. The anterior sclera was thickest in the inferior region and thinnest in the superior region (753.9 ± 88.7 μm versus 613.6 ± 58.4; p < 0.001). The AST in the temporal meridian was significantly thicker than that in the nasal meridian (727.5 ± 60.8, 690.9 ± 55 μm; p < 0.001). There were no significant variations in AST in the myopes and emmetropes along the five latitude lines. AST along the inferior meridian at the 4-mm (r 2 = 0.0992; p < 0.001) and 5-mm (r 2 = 0.0888; p < 0.001) locations decreased significantly with increasing myopia.

Conclusion: With increased myopia, AST at the 4-mm and 5-mm locations showed significant thinning in the inferior meridian. The results indicate that AST, especially along the inferior meridian, may act as a biologic marker to monitor the progression of myopia.

本刊更多论文

使用前节光学相干断层扫描评估近视眼和散光眼的前巩膜厚度。

目的：研究18-35岁中国成年人不同屈光状态下巩膜前厚度（AST）的差异：本研究招募了 170 名中国参与者（平均年龄为 24.06 ± 2.78 岁），包括近视（球面等效屈光度[SER] -1.00 至 -12.75 屈光度[D]；n = 134）、散光（SER ± 0.75 D；n = 36）和巩膜前厚度（AST）（上、下、鼻、颞），并通过扫源光学相干断层扫描进行了调查。半自动定制软件沿四条经线测量了从巩膜距到 5 毫米的巩膜厚度：平均轴长和球面等效屈光不正分别为 25.12 ± 1.44 mm 和 -3.93 ± 3.09 D。前巩膜下部最厚，上部最薄（753.9 ± 88.7 μm 对 613.6 ± 58.4；P < 0.001）。颞经的 AST 厚度明显高于鼻经（727.5 ± 60.8，690.9 ± 55 μm；p < 0.001）。五条纬线上的近视眼和散光眼的 AST 没有明显差异。随着近视度数的增加，沿下子午线 4 毫米（r 2 = 0.0992；p < 0.001）和 5 毫米（r 2 = 0.0888；p < 0.001）位置的 AST 显著下降：结论：随着近视度数的增加，4 毫米和 5 毫米位置的 AST 在下经线上明显变薄。结论：随着近视度数的增加，4 毫米和 5 毫米位置的 AST 在下子午线上明显变薄。结果表明，AST，尤其是沿下子午线的 AST，可作为监测近视进展的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.