Anayatollah Salimi, Soroush Jafarian, Arghavan Salimi, Saeed Mohammad Soleymani
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引用次数: 0
Abstract
Background: Valproic acid (VPA) is used to treat various neurological and psychiatric conditions. While oral VPA can cause hair loss, topical application has shown potential for hair regeneration. This study aimed to develop and evaluate microemulsion (ME) formulations of VPA for enhanced transfollicular delivery.
Methods: VPA-loaded MEs were prepared using oleic acid, Transcutol P, Tween 80, Labrasol, and Capryol 90. The MEs were characterized for physicochemical properties, stability, in vitro release, and ex vivo permeation through the hairy abdominal and nonhairy ear skin of guinea pigs.
Results: Eight stable ME formulations were developed with droplet sizes ranging from 10 to 24 nm, pH 4.6 to 5.2, and viscosity 77 to 85 cps. In vitro release studies showed controlled release profiles over 24 h. Permeation studies revealed enhanced drug delivery through both follicular and nonfollicular pathways compared with aqueous VPA solution. Formulations with higher surfactant/cosurfactant ratios showed increased permeation through the follicular pathway.
Conclusion: The ME formulations significantly enhanced VPA penetration into both epidermal and follicular pathways compared with aqueous solution. The composition of the MEs, particularly the oil content, water content, and surfactant/cosurfactant ratio, played a crucial role in determining the physicochemical properties and skin permeation parameters of VPA.
期刊介绍：
The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques.
The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.
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