Assessing the effectiveness of advanced platelet rich fibrin in treating gingival recession: a systematic review and meta-analysis.

IF 2.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

BMC Oral Health Pub Date : 2024-11-19 DOI:10.1186/s12903-024-05115-7

Wafaa Saleh, Marwa Abdelhaleem, Samah Elmeadawy

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引用次数: 0

Abstract

Objectives: The literature lacks comprehensive evidence on the efficacy of advanced platelet rich fibrin(A-PRF) in treating gingival recession. Therefore, this systematic review and meta-analysis aimed to evaluate the effectiveness of A-PRF in the treatment of gingival recession.

Materials and methods: We adhered to the guidelines of PRISMA in searching the following databases: PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, and Scopus to include all the eligible studies according to the prespecified inclusion and exclusion criteria. We conducted our search up to February 28, 2024. We conducted a meta-analysis of the primary and secondary clinical outcomes to measure the changes from baseline to 6 months after surgery.

Results: Our review included 10 randomized clinical trials in which 146 participants with 457 recession defects were included. We found that combination of A-PRF with various surgical techniques, such as coronally advanced flap (CAF) connective tissue graft (CTG), VISTA, tunneling, and pinhole surgical technique, demonstrated promising outcomes but varied by comparison group. We observed that CTG with CAF showed a higher reduction in recession depth in comparison to A-PRF with CAF. This review indicated no statistical or clinical differences in recession width, width of keratinized gingiva, probing depth, and clinical attachment level between the study and control groups.

Conclusions: Due to the less invasive nature of A-PRF, it provides a better clinical option to improve the outcomes of treating gingival recession. However, more well-designed RCTs with standardized approaches are needed to confirm these results.

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评估高级富血小板纤维蛋白治疗牙龈退缩的效果：系统综述和荟萃分析。

目的：关于高级富血小板纤维蛋白（A-PRF）治疗牙龈退缩的疗效，文献缺乏全面的证据。因此，本系统综述和荟萃分析旨在评估 A-PRF 治疗牙龈退缩的有效性：我们遵循 PRISMA 指南检索了以下数据库：PubMed/MEDLINE、Embase、Cochrane Library、Web of Science 和 Scopus，根据预先规定的纳入和排除标准纳入所有符合条件的研究。我们的搜索工作一直持续到 2024 年 2 月 28 日。我们对主要和次要临床结果进行了荟萃分析，以衡量从基线到术后 6 个月的变化：我们的综述包括 10 项随机临床试验，其中有 146 名参与者，457 例牙龈退缩缺损。我们发现，A-PRF 与冠状先进皮瓣 (CAF) 结缔组织移植 (CTG)、VISTA、隧道和针孔手术技术等多种手术技术的结合显示出良好的效果，但因比较组而异。我们观察到，与带有 CAF 的 A-PRF 相比，带有 CAF 的 CTG 显示出更大的后缩深度。综述显示，研究组和对照组在退缩宽度、角化牙龈宽度、探诊深度和临床附着水平方面没有统计学或临床差异：结论：由于 A-PRF 的微创性，它为改善牙龈退缩的治疗效果提供了更好的临床选择。然而，要证实这些结果，还需要更多设计良好、采用标准化方法的研究性临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

6.90%

发文量

481

审稿时长

6-12 weeks

期刊介绍： BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.