Bicyclic Ureas as JAK2 Inhibitors for Treating Hematological Cancer.

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-10-29 eCollection Date: 2024-11-14 DOI:10.1021/acsmedchemlett.4c00496

Ram W Sabnis

引用次数: 0

Abstract

Provided herein are novel bicyclic ureas as JAK2 inhibitors, pharmaceutical compositions, use of such compounds in treating hematological cancer, and processes for preparing such compounds.

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双环脲类作为 JAK2 抑制剂治疗血液肿瘤

本文提供了作为 JAK2 抑制剂的新型双环脲类、药物组合物、此类化合物在治疗血液肿瘤中的用途以及制备此类化合物的工艺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.