Enantioselective Nickel-Catalyzed Electrochemical Reductive Conjugate Alkenylation of α,β-Unsaturated Ketones

Abstract

Catalytic electrochemical asymmetric catalysis starting to emerg as a promising strategy for the synthesis of chiral compounds. Herein, we report an asymmetric electrochemical nickel-catalysed reductive conjugate addition of alkenyl bromides/aryl iodides to α,β-unsaturated ketones in an undivided cell, leading to the addition products with high yields and excellent enantioselectivities (up to 96% yield and 96% ee).