Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities.

IF 3.1 4区医学 Q2 PHARMACOLOGY & PHARMACY

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-04-01 Epub Date: 2024-11-19 DOI:10.1007/s00210-024-03603-9

Sherif S Abdel Mageed, Hanan Elimam, Ahmed E Elesawy, Ahmed I Abulsoud, Ahmed Amr Raouf, Manar Mohammed El Tabaa, Osama A Mohammed, Mohamed Bakr Zaki, Mai A Abd-Elmawla, Walaa A El-Dakroury, Safwat Abdelhady Mangoura, Mahmoud A Elrebehy, Mohammed S Elballal, Aya A Mohamed, Alaa Ashraf, Mustafa Ahmed Abdel-Reheim, Ali M S Eleragi, Hussein Abdellatif, Ahmed S Doghish

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引用次数: 0

Abstract

Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body's uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3' untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.

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揭示 miRNA 对痛风性关节炎的影响：诊断意义和治疗机会。

痛风性关节炎是一种常见的炎症性疾病。痛风发作的起因是体内尿酸代谢失衡，导致尿酸盐积聚并引发疾病。一种被称为微小RNA（miRNA）的保守的短非编码RNA家族可以通过附着在信使RNA（mRNA）的3'非翻译区（UTR）上来调节转录后蛋白质的合成。越来越多的研究表明，miRNAs 是包括痛风性关节炎在内的多种炎症性疾病的潜在参与者。miRNAs 可能通过调节免疫功能和炎症反应来影响疾病的进展。这篇综述主要关注 miRNA 及其对痛风性关节炎的影响。它还探讨了如何将 miRNAs 用作诊断、预后和潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Naunyn-Schmiedeberg's archives of pharmacology 医学-药学

CiteScore

6.20

自引率

5.60%

发文量

142

审稿时长

4-8 weeks

期刊介绍： Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.