Three-Dimensional Choroidal Vessels Assessment in Age-Related Macular Degeneration.

IF 5 2区医学 Q1 OPHTHALMOLOGY

Investigative ophthalmology & visual science Pub Date : 2024-11-04 DOI:10.1167/iovs.65.13.39

Elham Sadeghi, Nicola Valsecchi, Mohammed Nasar Ibrahim, Katherine Du, Elli Davis, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose Alain Sahel, Jay Chhablani

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引用次数: 0

Abstract

Purpose: To compare the choroidal vasculature in eyes with early- and intermediate-stage age-related macular degeneration (dAMD) and healthy using a novel three-dimensional algorithm.

Methods: Patients with dAMD and healthy controls underwent clinical examinations and swept-source optical coherence tomography scans (PlexElite-9000 device) centered on the fovea. Scans with quality scores >6 were included. Eyes with any signs of neovascular AMD or geographic atrophy were excluded. The choroidal layer was segmented using ResUNet model and volumetric smoothing. Phansalkar thresholding was used to binarize the choroidal vasculature. The three-dimensional maps were divided into five sectors. The three largest vessels in each sector were measured to determine the mean choroidal vessel diameter (MChVD) and inter-vessel distance (IVD). Volumetric choroidal thickness (ChT) and vascularity index (CVI) were also calculated.

Results: This retrospective cross-sectional study analyzed 60 eyes from 45 dAMD patients (27 early-stage, 33 intermediate-stage) and 26 eyes from 16 healthy controls. The average MChVD was increased in dAMD eyes compared to healthy eyes (239.559 ± 47.058 µm vs. 197.873 ± 49.047 µm, P < 0.001). The average MChVD in each sector increased significantly in eyes with dAMD (P < 0.05). The average IVD was increased significantly in dAMD eyes compared to healthy eyes (234.128 ± 69.537 µm vs. 179.914 ± 49.995 µm, P < 0.001). The average IVD in each sector was significantly increased in eyes with dAMD (P < 0.05). Average ChT and CVI in dAMD were reduced compared to healthy eyes (P < 0.05).

Conclusions: Eyes with dAMD demonstrated increased MChVD and IVD and decreased ChT and CVI, possibly related to smaller-vessel atrophy and larger-vessel dilation.

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年龄相关性黄斑变性的三维脉络膜血管评估

目的：使用新型三维算法比较早期和中期年龄相关性黄斑变性（dAMD）患者与健康人的脉络膜血管：dAMD患者和健康对照组接受了临床检查和以眼窝为中心的扫源光学相干断层扫描（PlexElite-9000设备）。扫描质量评分大于 6 分的患者被纳入其中。有任何新生血管性黄斑变性或地理萎缩迹象的眼球被排除在外。使用 ResUNet 模型和体积平滑技术分割脉络膜层。使用 Phansalkar 阈值对脉络膜血管进行二值化。三维地图被分为五个区域。测量每个区域中最大的三根血管，以确定脉络膜血管平均直径（MChVD）和血管间距（IVD）。此外，还计算了脉络膜的体积厚度（ChT）和血管指数（CVI）：这项回顾性横断面研究分析了 45 名 dAMD 患者（27 名早期患者，33 名中期患者）的 60 只眼睛和 16 名健康对照者的 26 只眼睛。与健康眼相比，dAMD 患者眼球的平均 MChVD 有所增加（239.559 ± 47.058 µm vs. 197.873 ± 49.047 µm，P < 0.001）。在患有 dAMD 的眼睛中，每个区段的平均 MChVD 显著增加（P < 0.05）。与健康眼睛相比，dAMD 眼睛的平均 IVD 明显增加（234.128 ± 69.537 µm vs. 179.914 ± 49.995 µm，P <0.001）。患有 dAMD 的眼睛每个区段的平均 IVD 显著增加（P < 0.05）。与健康眼相比，dAMD 患者的平均 ChT 和 CVI 降低（P < 0.05）：结论：dAMD 患者的 MChVD 和 IVD 增加，ChT 和 CVI 降低，这可能与小血管萎缩和大血管扩张有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative ophthalmology & visual science 医学-眼科学

CiteScore

6.90

自引率

4.50%

发文量

339

审稿时长

1 months

期刊介绍： Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.