Insights into the role of Streptococcus oralis as an opportunistic pathogen in infectious diseases.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI:10.3389/fcimb.2024.1480961

Jingyi Ren, Peng Sun, Meijuan Wang, Wenjuan Zhou, Zhonghao Liu

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Abstract

Streptococcus oralis, belonging to the viridans group streptococci (VGS), has been considered a member of normal flora mainly inhabiting the oral cavity. However, more recently, there has been growing recognition of its role as a causative agent in various life-threatening infectious diseases such as infective endocarditis (IE) and meningitis. Additionally, the differences in the prevalence, clinical features, and prognosis of opportunistic infections between S. oralis and other VGS species have been addressed. Particularly the predominance of S. oralis in IE has drawn critical attention. In potentially fatal infections, clinical neglect of S. oralis as an instigating agent might significantly impede early diagnosis and treatment. Nevertheless, to date, the infectious diseases associated with S. oralis have not yet been comprehensively described. Therefore, this review will give an overview of infectious diseases caused by S. oralis to uncover its hidden role as an opportunistic pathogen.

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洞察口腔链球菌作为机会性病原体在传染病中的作用。

口腔链球菌属于病毒群链球菌（VGS），一直被认为是主要栖息于口腔的正常菌群成员。但最近，人们越来越认识到它是各种危及生命的传染病（如感染性心内膜炎（IE）和脑膜炎）的致病菌。此外，口腔黏膜病菌与其他 VGS 物种在机会性感染的发病率、临床特征和预后方面的差异也得到了研究。尤其是口腔黏膜镰刀菌在 IE 中的主导地位引起了人们的高度关注。在可能致命的感染中，临床上忽视口腔黏膜镰刀菌作为诱因可能会严重阻碍早期诊断和治疗。然而，迄今为止，与口腔黏膜镰刀菌相关的感染性疾病尚未得到全面描述。因此，本综述将概述口腔黏膜镰刀菌引起的感染性疾病，以揭示其作为机会性病原体所隐藏的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.