Structural Elucidation and NMR Spectral Assignments of New Diphenyl Ether Derivatives From Liuweizhiji Gegen-Sangshen Oral Liquid.

IF 1.9 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Magnetic Resonance in Chemistry Pub Date : 2024-11-18 DOI:10.1002/mrc.5496

Jinghao Cui, Xin Zhou, Baorui Teng, Dan Zhang, Xiujuan Fu, Siwei Chen, Sijing Liu, Zhi Li, Hui Lei

引用次数: 0

Abstract

Chemical investigation of the Liuweizhiji Gegen-Sangshen oral liquid afforded one new diphenyl ether derivative (1), together with one known compound (2). Their structures were established by 1D and 2D NMR, and HR-ESI-MS spectroscopic analysis and the absolute configuration of 1 was confirmed by ECD calculation. Compounds 1 and 2 were evaluated for the cytotoxic activities, and compounds 1 and 2 showed weak cytotoxic activities towards HepG2 human liver cancer cells, with IC₅₀ values of 97.3 and 79.6 μM, respectively.

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六味地黄口服液中新的二苯醚衍生物的结构阐释和核磁共振谱定位

通过对六味地黄格根散口服液的化学研究，发现了一种新的二苯醚衍生物（1）和一种已知化合物（2）。通过一维和二维核磁共振以及 HR-ESI-MS 光谱分析确定了它们的结构，并通过 ECD 计算确认了 1 的绝对构型。对化合物 1 和 2 进行了细胞毒活性评估，结果表明，化合物 1 和 2 对 HepG2 人肝癌细胞具有微弱的细胞毒活性，IC50 值分别为 97.3 和 79.6 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance in Chemistry 化学-光谱学

CiteScore

4.70

自引率

10.00%

发文量

审稿时长

1 months

期刊介绍： MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.