New drug discovery and development from natural products: Advances and strategies

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Yixin Wang , Fan Wang , Wenxiu Liu , Yifei Geng , Yahong Shi , Yu Tian , Bin Zhang , Yun Luo , Xiaobo Sun
{"title":"New drug discovery and development from natural products: Advances and strategies","authors":"Yixin Wang ,&nbsp;Fan Wang ,&nbsp;Wenxiu Liu ,&nbsp;Yifei Geng ,&nbsp;Yahong Shi ,&nbsp;Yu Tian ,&nbsp;Bin Zhang ,&nbsp;Yun Luo ,&nbsp;Xiaobo Sun","doi":"10.1016/j.pharmthera.2024.108752","DOIUrl":null,"url":null,"abstract":"<div><div>Natural products (NPs) have a long history as sources for drug discovery, more than half of approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical treatment of complex diseases. However, bioactivity screening of NPs, target identification, and design optimization require continuously improved strategies, the complexity of drug mechanism of action and the limitations of technological strategies pose numerous challenges to the development of new drugs. This review begins with an overview of bioactivity- and target-based drug development patterns for NPs, advances in NP screening and derivatization, and the advantages and problems of major targets such as genes and proteins. Then, target-based drugs as well as identification and validation methods are further discussed to elucidate their mechanism of action. Subsequently, the current status and development trend of the application of traditional and emerging technologies in drug discovery and development of NPs are systematically described. Finally, the collaborative strategy of multi-technology integration and multi-disciplinary intersection is emphasized for the challenges faced in the identification, optimization, activity evaluation, and clinical application of NPs. It is hoped to provide a systematic overview and inspiration for exploring new drugs from natural resources in the future.</div></div>","PeriodicalId":402,"journal":{"name":"Pharmacology & Therapeutics","volume":"264 ","pages":"Article 108752"},"PeriodicalIF":12.0000,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacology & Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0163725824001724","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

Natural products (NPs) have a long history as sources for drug discovery, more than half of approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical treatment of complex diseases. However, bioactivity screening of NPs, target identification, and design optimization require continuously improved strategies, the complexity of drug mechanism of action and the limitations of technological strategies pose numerous challenges to the development of new drugs. This review begins with an overview of bioactivity- and target-based drug development patterns for NPs, advances in NP screening and derivatization, and the advantages and problems of major targets such as genes and proteins. Then, target-based drugs as well as identification and validation methods are further discussed to elucidate their mechanism of action. Subsequently, the current status and development trend of the application of traditional and emerging technologies in drug discovery and development of NPs are systematically described. Finally, the collaborative strategy of multi-technology integration and multi-disciplinary intersection is emphasized for the challenges faced in the identification, optimization, activity evaluation, and clinical application of NPs. It is hoped to provide a systematic overview and inspiration for exploring new drugs from natural resources in the future.
从天然产品中发现和开发新药物:进展与战略。
天然产物(NPs)作为药物发现的来源由来已久,超过一半的获批药物与 NPs 有关,在临床治疗复杂疾病方面也表现出多方面的优势。然而,NPs 的生物活性筛选、靶点识别和设计优化需要不断改进的策略,药物作用机制的复杂性和技术策略的局限性给新药研发带来了诸多挑战。本综述首先概述了基于生物活性和靶点的 NPs 药物开发模式、NP 筛选和衍生化的进展以及基因和蛋白质等主要靶点的优势和问题。然后,进一步讨论了基于靶点的药物以及鉴定和验证方法,以阐明其作用机制。随后,系统阐述了传统技术和新兴技术在 NPs 药物研发中的应用现状和发展趋势。最后,针对 NPs 在鉴定、优化、活性评价和临床应用中面临的挑战,强调了多技术整合和多学科交叉的合作策略。希望能为未来从自然资源中探索新药提供系统的概述和启发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信