Synthesis of Oxazolines using Aldol/Cyclization Cascade Reactions Employing 1,1-Diaminobenzalazine as Organocatalyst

Abstract

1,1-Diaminobenzalazine has been recently reported to catalyze different types of Michael addition reactions; this organic molecule has unique characteristic features for bifunctional organocatalysis. Organocatalysts were shown to be useful in different aldol/cyclization cascade reactions, it is important to establish whether 1,1-diaminobenzalazine can be employed in the aldol/cyclization cascade reactions. In this work, the synthesis of oxazolines with the help of organocatalyst, 1,1-diaminobenzalazine, has been reported. This method is relatively more efficient, cost-effective, and environmentally safe as it avoids the use of metal oxides as co-catalysts.