Graphene oxide-based fluorescent biosensors for pathogenic bacteria detection: a review

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2024-11-17 DOI:10.1016/j.aca.2024.343428

Shiwu Liu, Fangguo Lu, Shanquan Chen, Yi Ning

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引用次数: 0

Abstract

Background

Pathogenic bacteria are widespread in nature and can cause infections and various complications, thereby posing a severe risk to public health. Therefore, simple, rapid, sensitive, and cost-effective methods must be developed to detect pathogenic bacteria. Biosensors are prominent platforms for detecting pathogenic bacteria owing to their high sensitivity, specificity, repeatability, and stability. With the development of nanotechnology, graphene oxide (GO) has been increasingly introduced into the construction of fluorescent biosensors to enhance their performance owing to its unique physicochemical properties.

Results

This review systematically summarizes the development of GO-based fluorescent biosensors for the detection of pathogenic bacteria. First, we introduce the functionalization and modification of GO. The design and signal amplification strategies for GO-based fluorescent biosensors are also discussed. Finally, we explore the challenges and new perspectives associated with this field, with the aim of facilitating the development of GO-based fluorescent sensing technologies to prevent the spread of multidrug-resistant bacteria.

Significance

This review will aid in the development of high-performance biosensors for pathogenic bacterial assays.

Abstract Image

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基于氧化石墨烯的病原菌检测荧光生物传感器：综述

背景致病菌在自然界中广泛存在，可引起感染和各种并发症，从而对公众健康构成严重威胁。因此，必须开发简单、快速、灵敏和经济有效的方法来检测致病细菌。生物传感器因其高灵敏度、特异性、可重复性和稳定性而成为检测致病细菌的重要平台。随着纳米技术的发展，氧化石墨烯（GO）因其独特的物理化学特性被越来越多地引入到荧光生物传感器的构建中，以提高其性能。首先，我们介绍了 GO 的功能化和修饰。还讨论了基于 GO 的荧光生物传感器的设计和信号放大策略。最后，我们探讨了与这一领域相关的挑战和新视角，旨在促进基于 GO 的荧光传感技术的发展，以防止多重耐药细菌的传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.