Effect of active oxygen gel on the clinical parameters of MRONJ

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Saudi Dental Journal Pub Date : 2024-11-01 DOI:10.1016/j.sdentj.2024.09.003

Bruna Cristina de Cristo , Hassan Yousef Saleh , Suyany Weiss , Aline Sebastiani , Mohammed Elsalanty , Rafaela Scariot , Tatiana Miranda Deliberador

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引用次数: 0

Abstract

Purpose

The aim of this work was to evaluate the effectiveness of a gel with active oxygen in the prevention of MRONJ.

Methods

Using split-mouth study design, twelve Wistar rats were used, females (n = 6) and males (n = 6). All rats received a weekly intravenous injection of zoledronate (80 μg / kg body weight in PBS) for 8 weeks. Then, the animals underwent surgery to remove the first and second right and left mandibular molars to induce osteonecrosis. The animals received topical application of oxygen gel (blue®m) on the right-side extraction site (Group T) 3 times a week until euthanasia after 6 weeks, with no intervention on the left side (Group C). The clinical parameters analyzed included the presence and dimension of bone exposure, suppuration and epithelialization.

Results

Statistical analysis using chi-square and Mann-Whitney test (p value < 0.05) demonstrated that group C had more severe signs of MRONJ at euthanasia than in the group T.

Conclusion

Within the limitations of this pilot study, we can conclude that the application of active oxygen gel could be beneficial in the prevention of MRONJ.

查看原文本刊更多论文

活性氧凝胶对 MRONJ 临床参数的影响

方法采用分口研究设计，使用 12 只 Wistar 大鼠，雌性（n = 6）和雄性（n = 6）。所有大鼠每周静脉注射唑来膦酸钠（80 μg / kg 体重，PBS）8 周。然后，动物接受手术，拔除左右下颌第一和第二磨牙，以诱导骨坏死。动物在右侧拔牙部位（T组）接受氧凝胶（蓝®m）外敷，每周3次，直至6周后安乐死，左侧拔牙部位（C组）不接受干预。结果使用卡方检验和曼-惠特尼检验（p 值为 0.05）进行的统计分析表明，C 组动物在安乐死时的 MRONJ 症状比 T 组严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.