Recent developments in the metal-free synthesis of oxazoles

Abstract

Oxazoles found a very prominent position in heterocyclic and medicinal chemistry. Several methods of synthesizing these species were introduced, and recent efforts have been made to generate these species using metal-free methods in a highly efficient manner. In the past decade, many novel metal-free methods of synthesizing oxazoles have been emerged. A cursory glance at these methods indicated that it is possible to classify the reported methods on the basis of the proposed mechanisms. This review provides an overview of all these methods along with mechanistic details and tries to find some commonalities among these.