A computational model to design wide field-of-view optic nerve neuroprostheses

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-11-05 DOI:10.1016/j.isci.2024.111321

Simone Romeni , Daniela De Luca , Luca Pierantoni , Laura Toni , Gabriele Marino , Sara Moccia , Silvestro Micera

引用次数: 0

Abstract

Retinal stimulation (RS) allows restoring vision in blind patients, but it covers only a narrow region of the visual field. Optic nerve stimulation (ONS) has the potential to produce visual perceptions spanning the whole visual field, but it produces very irregular phosphenes. We introduced a geometrical model converting retinal and optic nerve firing rates into visual perceptions and vice versa and a method to estimate the best perceptions elicitable through an electrode configuration. We then compared in silico ONS and RS through simulated prosthetic vision of static and dynamic visual scenes. Both simulations and SPV experiments showed that it might be possible to reconstruct natural visual scenes with ONS and RS, and that ONS wide field-of-view allows the perception of more detail in dynamic scenarios than RS. Our findings suggest that ONS could represent an interesting approach for vision restoration and that our model can be used to optimize it.

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设计宽视场视神经假体的计算模型

视网膜刺激（RS）可以让失明患者恢复视力，但它只能覆盖视野的一个狭窄区域。视神经刺激（ONS）有可能产生跨越整个视野的视觉感知，但它产生的幻视非常不规则。我们引入了一个几何模型，将视网膜和视神经的发射率转换为视觉感知，反之亦然。然后，我们通过对静态和动态视觉场景的模拟义眼，比较了硅ONS和RS。模拟和 SPV 实验都表明，使用 ONS 和 RS 有可能重建自然视觉场景，而且 ONS 的宽视场比 RS 能够感知动态场景中更多的细节。我们的研究结果表明，ONS 可能是一种有趣的视觉恢复方法，我们的模型可用于对其进行优化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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