Communication subspace dynamics of the canonical olfactory pathway

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-10-28 DOI:10.1016/j.isci.2024.111275

Joaquín Gonzalez , Pablo Torterolo , Kevin A. Bolding , Adriano B.L. Tort

引用次数: 0

Abstract

Understanding how different brain areas communicate is crucial for elucidating the mechanisms underlying cognition. A possible way for neural populations to interact is through a communication subspace, a specific region in the state-space enabling the transmission of behaviorally relevant spiking patterns. In the olfactory system, it remains unclear if different populations employ such a mechanism. Our study reveals that neuronal ensembles in the main olfactory pathway (olfactory bulb to olfactory cortex) interact through a communication subspace, which is driven by nasal respiration and allows feedforward and feedback transmission to occur segregated along the sniffing cycle. Moreover, our results demonstrate that subspace communication depends causally on the activity of both areas, is hindered during anesthesia, and transmits a low-dimensional representation of odor.

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典型嗅觉通路的通信子空间动力学

了解不同脑区如何进行交流对于阐明认知的内在机制至关重要。神经群相互作用的一种可能方式是通过通信子空间，即状态空间中能够传输与行为相关的尖峰模式的特定区域。在嗅觉系统中，不同的神经群是否采用了这种机制仍不清楚。我们的研究揭示了主要嗅觉通路（嗅球到嗅皮层）中的神经元集合通过通信子空间相互作用，该子空间由鼻呼吸驱动，允许前馈和反馈传输沿着嗅觉周期发生分离。此外，我们的研究结果表明，子空间通信与两个区域的活动有因果关系，在麻醉期间会受到阻碍，并传输低维的气味表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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